Science

Imitex has created a substantial suite of intellectual property regarding the activation of MEF2. This asset draws on more than 20 years of experience combined with cutting-edge AI and quantum drug discovery tools to identify and develop new therapeutics.

The articles below provide insights into Professor McGee’s research – and related studies – that validate MEF2 as a high-priority target for therapeutic development.

Scientific Publications

McGee Lab

Disruption of histone deacetylase activity improves markers of whole-body metabolism
Gaur V et al. Cell Reports 16:2802–2810 (2016)
Exercise increases MEF2- and GEF DNA-binding activity in human skeletal muscle
McGee SL et al. FASEB Journal 20:348–349 (2006)
(Note: This is a brief communication/abstract in FASEB J; full text access may require a subscription.)
Exercise and MEF2 regulation in human skeletal muscle
McGee SL et al. Diabetes 53:1208–1214 (2004)

Independent Validation

Our MEF2 research has been independently validated by the Molecular Transducers of Physical Activity (MoTrPAC) consortium in Nature (2024) – reinforcing MEF2's critical role in exercise adaptation.

Temporal dynamics of the multi-omic response to endurance exercise training
NIH MoTrPAC Study Group. Nature 629:174–183 (2024)